MacuHealth with LMZ3

A lifetime of macular health and improved visual performance

Advancement in the understanding of vision and macular disease has revolutionized and irreversibly changed our role as ophthalmic clinicians. We can no longer plead ignorance when it comes to promoting and maintaining ocular health, maximizing vision and preventing macular degeneration. Clinicians are now medically responsible for educating our patients and legally responsible for advising the latest strategies to maintain ocular health, early detection of macular disease and timely intervention to attenuate disease progression. Like it or not, the future of our feld requires that we understand the political, molecular and clinical basis of ocular nutrition and pathogenesis of age-related macular diseases.


Ocular Nutrition

Ocular nutrition has been guided in the past by clinical anecdote rather than science. Without food and drug administration (FDA) oversight and lack of pathogenic understanding of eye disease, proof of efcacy and safety were replaced by marketing and opinion. With the advancement in the scientifc understanding of normal ocular health and ocular pathologies like macular degeneration, ocular nutrition now must be examined under the microscope of molecular science and safety.


FDA Oversight

Without FDA oversight, many nutrients are used in extremely high doses, which amplify both their potentially therapeutic efects and their accompanying toxicities. Vitamin A is an example of a necessary nutrient at normal doses converted into a carcinogen at higher doses.1,2 Zinc is also another ocular nutrient that in normal doses is healthy but in higher doses it can be carcinogenic, predispose to genitourinary problems and is amyloidogenic.3-12


Vitamin A

Vitamin A is actually the fuel for the visual cycle and while necessary in recommended amounts, in high doses is similar to treating diabetes with sugar. Zinc also is a Jekyll and Hyde element; in Alzheimer’s and prostate health, it is the homeostasis of zinc that is pathogenic and why too much and too little zinc can potentiate cancer and amyloid formation.

In the eyes, zinc over the long term appears to demonstrate its strong anti-angiogenic properties14 by reducing the risk of choroidal neovascularization in AMD,15 but also promotes its apoptogenic properties16 as it potentially accelerates the development of central involving geographic atrophy.15